diff --git a/CHANGELOG.md b/CHANGELOG.md
index 39869a78..f66bc473 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,5 +1,9 @@
 # Changelog
 
+### v5.0.0-rc.1 (???)
+
+- **[BREAKING]** Add interoperable TTFB to measure Early Hints consistently ([#566](https://github.com/GoogleChrome/web-vitals/pull/566))
+
 ### v5.0.0-rc.0 (2024-10-03)
 
 - **[BREAKING]** Remove the deprecated `onFID()` function ([#519](https://github.com/GoogleChrome/web-vitals/pull/519))
diff --git a/src/attribution/onLCP.ts b/src/attribution/onLCP.ts
index 1faa264d..1659089e 100644
--- a/src/attribution/onLCP.ts
+++ b/src/attribution/onLCP.ts
@@ -83,7 +83,13 @@ export const onLCP = (
 
         const ttfb = Math.max(
           0,
-          navigationEntry.responseStart - activationStart,
+          // From Chrome 115 until 133, Chrome reported responseStart as the
+          // document bytes, rather than Early Hint bytes. Prefer the Early
+          // Hint bytes (firstInterimResponseStart) for consistency with other
+          // browers, but only if non-zero (so use || rather than ??) as zero
+          // indicates no early hints.
+          (navigationEntry.firstInterimResponseStart ||
+            navigationEntry.responseStart) - activationStart,
         );
 
         const lcpRequestStart = Math.max(
diff --git a/src/onTTFB.ts b/src/onTTFB.ts
index 721dca0e..9a87febf 100644
--- a/src/onTTFB.ts
+++ b/src/onTTFB.ts
@@ -71,14 +71,20 @@ export const onTTFB = (
     const navigationEntry = getNavigationEntry();
 
     if (navigationEntry) {
+      // From Chrome 115 until 133, Chrome reported responseStart as the
+      // document bytes, rather than Early Hint bytes. Prefer the Early Hint
+      // bytes (firstInterimResponseStart) for consistency with other
+      // browers, but only if non-zero (so use || rather than ??) as zero
+      // indicates no early hints.
+      const responseStart =
+        navigationEntry.firstInterimResponseStart ||
+        navigationEntry.responseStart;
+
       // The activationStart reference is used because TTFB should be
       // relative to page activation rather than navigation start if the
       // page was prerendered. But in cases where `activationStart` occurs
       // after the first byte is received, this time should be clamped at 0.
-      metric.value = Math.max(
-        navigationEntry.responseStart - getActivationStart(),
-        0,
-      );
+      metric.value = Math.max(responseStart - getActivationStart(), 0);
 
       metric.entries = [navigationEntry];
       report(true);
diff --git a/src/types.ts b/src/types.ts
index 34d3a7ca..edc3db5f 100644
--- a/src/types.ts
+++ b/src/types.ts
@@ -53,9 +53,12 @@ declare global {
     durationThreshold?: number;
   }
 
-  // https://wicg.github.io/nav-speculation/prerendering.html#performance-navigation-timing-extension
   interface PerformanceNavigationTiming {
+    // https://wicg.github.io/nav-speculation/prerendering.html#performance-navigation-timing-extension
     activationStart?: number;
+    // https://w3c.github.io/resource-timing/#dom-performanceresourcetiming-firstinterimresponsestart
+    firstInterimResponseStart?: number;
+    finalResponseHeadersStart?: number;
   }
 
   // https://wicg.github.io/event-timing/#sec-performance-event-timing
diff --git a/test/e2e/onTTFB-test.js b/test/e2e/onTTFB-test.js
index 07e34fb1..20a167ee 100644
--- a/test/e2e/onTTFB-test.js
+++ b/test/e2e/onTTFB-test.js
@@ -398,6 +398,44 @@ describe('onTTFB()', async function () {
       assert.strictEqual(ttfb.attribution.requestDuration, 0);
       assert.strictEqual(ttfb.attribution.navigationEntry, undefined);
     });
+
+    it('reports the correct value for Early Hints', async function () {
+      await navigateTo(
+        // '/test/ttfb?responseStart=10&earlyHintsDelay=50&attribution=1',
+        '/test/ttfb?earlyHintsDelay=50&attribution=1',
+      );
+
+      const ttfb = await getTTFBBeacon();
+
+      if ('finalResponseHeadersStart' in ttfb.attribution.navigationEntry) {
+        assert.strictEqual(
+          ttfb.value,
+          ttfb.attribution.navigationEntry.responseStart,
+        );
+        assert.strictEqual(
+          ttfb.value,
+          ttfb.attribution.navigationEntry.firstInterimResponseStart,
+        );
+        assert(
+          ttfb.value <
+            ttfb.attribution.navigationEntry.finalResponseHeadersStart,
+        );
+      } else if (
+        'firstInterimResponseStart' in ttfb.attribution.navigationEntry
+      ) {
+        // TODO: Can remove these after Chrome 133 lands and above is used.
+        assert(ttfb.value < ttfb.attribution.navigationEntry.responseStart);
+        assert.strictEqual(
+          ttfb.value,
+          ttfb.attribution.navigationEntry.firstInterimResponseStart,
+        );
+      } else {
+        assert.strictEqual(
+          ttfb.value,
+          ttfb.attribution.navigationEntry.responseStart,
+        );
+      }
+    });
   });
 });
 
diff --git a/test/server.js b/test/server.js
index ff666576..5d13d4b0 100644
--- a/test/server.js
+++ b/test/server.js
@@ -39,6 +39,19 @@ app.use((req, res, next) => {
   }
 });
 
+// Allow the use of a `earlyHintsDelay` query param to delay any response
+// after sending an early hints
+app.use((req, res, next) => {
+  if (req.query && req.query.earlyHintsDelay) {
+    res.writeEarlyHints({
+      'link': '</styles.css>; rel=preload; as=style',
+    });
+    setTimeout(next, req.query.earlyHintsDelay);
+  } else {
+    next();
+  }
+});
+
 // Add a "collect" endpoint to simulate analytics beacons.
 app.post('/collect', bodyParser.text(), (req, res) => {
   // Uncomment to log the metric when manually testing.