diff --git a/.github/workflows/mutation_testing.yml b/.github/workflows/mutation_testing.yml
new file mode 100644
index 000000000000..7fde6885bd52
--- /dev/null
+++ b/.github/workflows/mutation_testing.yml
@@ -0,0 +1,32 @@
+name: Run Cargo Mutants
+
+on:
+  workflow_dispatch:
+
+jobs:
+  mutation-testing:
+    name: Mutation Testing with cargo-mutants
+    runs-on: ubuntu-latest
+
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v4
+
+      - name: Install Rust
+        uses: dtolnay/rust-toolchain@stable
+
+      - name: Cache Cargo dependencies
+        uses: actions/cache@v3
+        with:
+          path: |
+            ~/.cargo/registry
+            ~/.cargo/git
+            target
+          key: cargo-${{ runner.os }}-${{ hashFiles('**/Cargo.lock') }}
+          restore-keys: cargo-${{ runner.os }}-
+
+      - name: Install cargo-mutants
+        run: cargo install cargo-mutants
+
+      - name: Run Mutation Tests
+        run: cargo mutants --baseline skip --in-place
diff --git a/mutants.toml b/mutants.toml
new file mode 100644
index 000000000000..e65fe93403c9
--- /dev/null
+++ b/mutants.toml
@@ -0,0 +1,12 @@
+[cargo]
+test = [
+    "--profile", "ci",
+    "--exclude", "datafusion-examples",
+    "--exclude", "ffi_example_table_provider",
+    "--exclude", "datafusion-benchmarks",
+    "--workspace",
+    "--lib",
+    "--tests",
+    "--bins",
+    "--features", "avro,json,backtrace,integration-tests",
+]