diff --git a/channels_redis/pubsub.py b/channels_redis/pubsub.py
index a80e12d..306b630 100644
--- a/channels_redis/pubsub.py
+++ b/channels_redis/pubsub.py
@@ -3,6 +3,7 @@
 import logging
 import uuid
 
+import aioredlock
 from redis import asyncio as aioredis
 
 from .serializers import registry
@@ -117,6 +118,11 @@ def __init__(
             RedisSingleShardConnection(host, self) for host in decode_hosts(hosts)
         ]
 
+        # Create lock manager for all redis connections
+        redis_connections = [shard.host for shard in self._shards]
+        self._lock_manager = aioredlock.Aioredlock()
+        self._lock_manager.redis_connections = redis_connections
+
     def _get_shard(self, channel_or_group_name):
         """
         Return the shard that is used exclusively for this channel or group.
@@ -135,10 +141,21 @@ def _get_group_channel_name(self, group):
         """
         return f"{self.prefix}__group__{group}"
 
+    async def _acquire_lock(self, channel):
+        try:
+            await self._lock_manager.lock(channel, lock_timeout=60)
+        except aioredlock.LockError:
+            logger.debug("Failed to acquire lock on channel %s", channel)
+            return False
+
+        return True
+
     async def _subscribe_to_channel(self, channel):
         self.channels[channel] = asyncio.Queue()
-        shard = self._get_shard(channel)
-        await shard.subscribe(channel)
+
+        if await self._acquire_lock(channel):
+            shard = self._get_shard(channel)
+            await shard.subscribe(channel)
 
     extensions = ["groups", "flush"]
 
diff --git a/setup.py b/setup.py
index a368709..96a3713 100644
--- a/setup.py
+++ b/setup.py
@@ -31,6 +31,7 @@
     include_package_data=True,
     python_requires=">=3.8",
     install_requires=[
+        "aioredlock>=0.7.3,<1",
         "redis>=4.6",
         "msgpack~=1.0",
         "asgiref>=3.2.10,<4",
diff --git a/tests/test_pubsub.py b/tests/test_pubsub.py
index 3c00dd6..5ec33d9 100644
--- a/tests/test_pubsub.py
+++ b/tests/test_pubsub.py
@@ -5,8 +5,8 @@
 
 import async_timeout
 import pytest
-
 from asgiref.sync import async_to_sync
+
 from channels_redis.pubsub import RedisPubSubChannelLayer
 from channels_redis.utils import _close_redis
 
@@ -261,3 +261,45 @@ async def test_discard_before_add(channel_layer):
     channel_name = await channel_layer.new_channel(prefix="test-channel")
     # Make sure that we can remove a group before it was ever added without crashing.
     await channel_layer.group_discard("test-group", channel_name)
+
+
+@pytest.mark.asyncio
+async def test_guarantee_at_most_once_delivery() -> None:
+    """
+    Tests that at most once delivery is guaranteed.
+
+    If two consumers are listening on the same channel,
+    the message should be delivered to only one of them.
+    """
+
+    channel_name = "same-channel"
+    loop = asyncio.get_running_loop()
+
+    channel_layer = RedisPubSubChannelLayer(hosts=TEST_HOSTS)
+    channel_layer_2 = RedisPubSubChannelLayer(hosts=TEST_HOSTS)
+    future_channel_layer = loop.create_future()
+    future_channel_layer_2 = loop.create_future()
+
+    async def receive_task(
+        channel_layer: RedisPubSubChannelLayer, future: asyncio.Future
+    ) -> None:
+        message = await channel_layer.receive(channel_name)
+        future.set_result(message)
+
+    # Ensure that receive_task_2 is scheduled first and accquires the lock
+    asyncio.create_task(receive_task(channel_layer_2, future_channel_layer_2))
+    await asyncio.sleep(1)
+    asyncio.create_task(receive_task(channel_layer, future_channel_layer))
+    await asyncio.sleep(1)
+
+    await channel_layer.send(channel_name, {"type": "test.message", "text": "Hello!"})
+
+    result = await future_channel_layer_2
+    assert result["type"] == "test.message"
+    assert result["text"] == "Hello!"
+
+    # Channel layer 1 should not receive the message
+    # as it is already consumed by channel layer 2
+    with pytest.raises(asyncio.TimeoutError):
+        async with async_timeout.timeout(1):
+            await future_channel_layer