diff --git a/README.md b/README.md
index c74a4c266..6916d99d6 100644
--- a/README.md
+++ b/README.md
@@ -156,6 +156,7 @@ App|Description
 [uart_tx](pio/uart_tx)| Implement the transmit component of a UART serial port, and print hello world.
 [ws2812](pio/ws2812)| Examples of driving WS2812 addressable RGB LEDs.
 [addition](pio/addition)| Add two integers together using PIO. Only around 8 billion times slower than Cortex-M0+.
+[irq](pio/irq)| Respond to interrupts generated by a PIO state machine.
 
 ### PWM
 
diff --git a/pio/CMakeLists.txt b/pio/CMakeLists.txt
index 0b9d0b3ac..8684fc519 100644
--- a/pio/CMakeLists.txt
+++ b/pio/CMakeLists.txt
@@ -18,4 +18,5 @@ if (NOT PICO_NO_HARDWARE)
     add_subdirectory(uart_rx)
     add_subdirectory(uart_tx)
     add_subdirectory(ws2812)
+    add_subdirectory(irq)
 endif ()
diff --git a/pio/irq/CMakeLists.txt b/pio/irq/CMakeLists.txt
new file mode 100644
index 000000000..c16185ee1
--- /dev/null
+++ b/pio/irq/CMakeLists.txt
@@ -0,0 +1,18 @@
+add_executable(pio_irq)
+
+pico_generate_pio_header(pio_irq ${CMAKE_CURRENT_LIST_DIR}/simple_irq.pio)
+
+target_sources(pio_irq PRIVATE main.c)
+
+pico_enable_stdio_usb(pio_irq 1)
+pico_enable_stdio_uart(pio_irq 0)
+
+target_link_libraries(pio_irq PRIVATE
+        pico_stdlib
+        hardware_pio
+        )
+
+pico_add_extra_outputs(pio_irq)
+
+# add url via pico_set_program_url
+example_auto_set_url(pio_irq)
diff --git a/pio/irq/main.c b/pio/irq/main.c
new file mode 100644
index 000000000..341c6862a
--- /dev/null
+++ b/pio/irq/main.c
@@ -0,0 +1,174 @@
+/**
+ * Copyright 2022 (c) Daniel Garcia-Briseno
+ *
+ * Redistribution and use in source and binary forms, with or without modification, are permitted provided that the
+ * following conditions are met:
+ * 
+ * 1. Redistributions of source code must retain the above copyright notice, this list of conditions and the following
+ *    disclaimer.
+ * 
+ * 2. Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following
+ *    disclaimer in the documentation and/or other materials provided with the distribution.
+ * 
+ * 3. Neither the name of the copyright holder nor the names of its contributors may be used to endorse or promote products
+ *    derived from this software without specific prior written permission.
+ * 
+ * THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES,
+ * INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE
+ * DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL,
+ * SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR
+ * SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY,
+ * WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF
+ * THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
+ */
+
+#include <stdio.h>
+#include "pico/stdlib.h"
+
+#include "simple_irq.pio.h"
+
+/**
+ * These defines represent each state machine.
+ * I'll use these to flag which state machine fired the ISR
+ */
+#define PIO_SM_0_IRQ 0b0001
+#define PIO_SM_1_IRQ 0b0010
+#define PIO_SM_2_IRQ 0b0100
+#define PIO_SM_3_IRQ 0b1000
+
+
+/**
+ * This variable will shadow the IRQ flags set by the PIO state machines.
+ * Typically you do not want to do work in ISRs because the main thread
+ * has more important things to do. Because of that, when we get the ISR
+ * I'm going to copy the state machine that fired the ISR into this
+ * variable.
+ *
+ * Variable is volatile so that it doesn't get cached in a CPU register
+ * in the main thread. Without this it's possible that you never see
+ * irq_flags get set even though the ISR is firing all the time.
+ *
+ * Of course, you can really do whatever you want in the ISR, it's up to you.
+ */
+volatile uint8_t irq_flags = 0;
+
+/**
+ * This function is called when the IRQ is fired by the state machine.
+ * @note See enable_pio_irqs for how to register this function to be called
+ */
+void simple_irq_handler() {
+    // Check the interrupt source and set the flag accordingly
+    // This method can handle multiple simultaneous interrupts from the PIO
+    // since it checks all the irq flags. The advantage to this is that the
+    // ISR would execute only once when simultaneous interrupts happen instead
+    // of being executed for each interrupt individually.
+    // For other applications, make sure to check the correct pio (pio0/pio1)
+    irq_flags = pio0_hw->irq;
+    // Clear the flags since we've saved them to check later.
+    hw_clear_bits(&pio0_hw->irq, irq_flags);
+
+    // alternatively you could use pio_interrupt_get(pio0, #) to check a specific
+    // irq flag.
+}
+
+/**
+ * Lets the pico know that we want it to notify us of the PIO ISRs.
+ * @note in simple_irq.pio we enable irq0. This tells the state machine
+ *       to send the ISRs to the core, we still need to tell the core
+ *       to send them to our program.
+ */
+void enable_pio_irqs() {
+    // Set the function that will be called when the PIO IRQ comes in.
+    irq_set_exclusive_handler(PIO0_IRQ_0, simple_irq_handler);
+
+    // Once that function is set, we can go ahead and allow the interrupts
+    // to come in. You want to set the function before enabling the interrupt
+    // just in case. The docs say if an IRQ comes in and there's no handler
+    // then it will work like a breakpoint, which seems bad.
+    irq_set_enabled(PIO0_IRQ_0, true);
+}
+
+/**
+ * Loads simple_irq pio program into PIO memory
+ */
+void load_pio_programs() {
+    PIO pio = pio0;
+
+    // Load the program into PIO memory
+    uint offset = pio_add_program(pio, &simple_irq_program);
+
+    // Tell each state machine to run the program.
+    // They are allowed to run the same program in memory.
+    simple_irq_program_init(pio, 0, offset);
+    simple_irq_program_init(pio, 1, offset);
+    simple_irq_program_init(pio, 2, offset);
+    simple_irq_program_init(pio, 3, offset);
+}
+
+/**
+ * Writes to the tx fifo of the given state machine.
+ * This will make the simple_irq program send an ISR to us!
+ */
+void trigger_irq(int sm) {
+    printf("Triggering ISR from state machine %d\n", sm);
+    pio_sm_put_blocking(pio0, sm, 1);
+    // Interrupt will fire from the pio right here since they trigger
+    // whenever data goes into the TX FIFO, see simple_irq.pio
+
+    // Print the irq we expect based on the given state machine
+    printf("Expected IRQ flags: 0x%08X\n", (1 << sm));
+    printf("Actual IRQ Flags: 0x%08X\n", irq_flags);
+
+    // Here you could dispatch work for the irq depending one
+    // flagged it. The work should be done here rather than inside
+    // the irq function. While executing code in an irq, no other
+    // irq's can execute. By having the processing code outside of
+    // the irq, we can still be responsive to new irqs.
+    if (irq_flags & PIO_SM_0_IRQ) {
+        // handle_sm0_irq();
+    }
+    if (irq_flags & PIO_SM_1_IRQ) {
+        // handle_sm1_irq();
+    }
+    if (irq_flags & PIO_SM_2_IRQ) {
+        // handle_sm2_irq();
+    }
+    if (irq_flags & PIO_SM_3_IRQ) {
+        // handle_sm3_irq();
+    }
+    
+    // clear irq flags now.
+    irq_flags = 0;
+}
+
+int main() {
+    // Init stdio
+    stdio_init_all();
+
+    // Load simple_irq into memory
+    load_pio_programs();
+
+    // Enable IRQs to respond to simple_irq
+    enable_pio_irqs();
+
+    // simple_irq is programmed to fire an ISR when we write
+    // to their tx fifo. So let's do that now.
+    while (true) {
+        // Fire state machine 0
+        trigger_irq(0);
+        sleep_ms(1000);
+
+        // Fire state machine 1
+        trigger_irq(1);
+        sleep_ms(1000);
+
+        // Fire state machine 2
+        trigger_irq(2);
+        sleep_ms(1000);
+
+        // Fire state machine 3
+        trigger_irq(3);
+        sleep_ms(1000);
+    }
+}
+
diff --git a/pio/irq/simple_irq.pio b/pio/irq/simple_irq.pio
new file mode 100644
index 000000000..934ef2eb6
--- /dev/null
+++ b/pio/irq/simple_irq.pio
@@ -0,0 +1,72 @@
+; Copyright (c) 2022 Daniel Garcia-Briseno
+;
+; Redistribution and use in source and binary forms, with or without modification, are permitted provided that the
+; following conditions are met:
+; 
+; 1. Redistributions of source code must retain the above copyright notice, this list of conditions and the following
+;    disclaimer.
+; 
+; 2. Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following
+;    disclaimer in the documentation and/or other materials provided with the distribution.
+; 
+; 3. Neither the name of the copyright holder nor the names of its contributors may be used to endorse or promote products
+;    derived from this software without specific prior written permission.
+; 
+; THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES,
+; INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE
+; DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL,
+; SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR
+; SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY,
+; WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF
+; THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
+
+.program simple_irq
+
+; Stall on OSR. Wait for software to send a signal to continue
+; by writing to the OSR
+out x, 1
+
+; Do work here
+nop
+
+; Notify the software via irq that some work has been done
+; irq wait means to wait for software to acknowledge the irq before
+; continuing. rel means let the irq be relative to the state machine.
+; by using "0 rel" on all state machines, software will see a different
+; interrupt source for each state machine. Technically state machines
+; can set any irq source, so in order to know where the irq is coming from
+; it's best to set 0 rel
+irq wait 0 rel
+
+% c-sdk {
+    /**
+     * Initializer for the fake irq program program
+     * @param[in] pio the PIO instance to use
+     * @param[in] sm state machine to use for the PIO instance
+     * @param[in] offset Offset into PIO memory to place the program into
+     */
+    static inline void simple_irq_program_init(PIO pio, uint sm, uint offset) {
+        // Enable the IRQ source
+        // The reason for doing interrupt0 + sm:
+        // IRQ sources are enabled per irq flag. Since the irq flag being set depends on the state
+        // machine because of the "0 rel", we want to make sure we're enabling the correct interrupt
+        // source for the state machine the program is loaded into. 
+        pio_set_irq0_source_enabled(pio, (pis_interrupt0 + sm), true);
+        // Make sure the interrupt starts cleared. It should already be cleared, so this should
+        // basically be a no-op. I call it defensive programming.
+        pio_interrupt_clear(pio, sm);
+
+        // Build the configuration for the state machine
+        pio_sm_config config = simple_irq_program_get_default_config(offset);
+
+        // Set up autopull to pull the TX Fifo into the OSR
+        // This is what actually makes the "out" instruction wait
+        // for input from software.
+        // params are (config, shift_right (ignored here), autopull (true), pull threshold (1 bit))
+        sm_config_set_out_shift(&config, true, true, 1);
+
+        // Load the config and execute the state machine
+        pio_sm_init(pio, sm, offset, &config);
+        pio_sm_set_enabled(pio, sm, true);
+    }
+%}