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@pinellolab

Pinello Lab

Massachusetts General Hospital/Harvard Medical School

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  1. STREAM Public

    STREAM: Single-cell Trajectories Reconstruction, Exploration And Mapping of single-cell data

    Jupyter Notebook 176 50

  2. CRISPResso2 Public

    Analysis of deep sequencing data for rapid and intuitive interpretation of genome editing experiments

    Python 298 100

  3. haystack_bio Public

    Haystack: Epigenetic Variability and Transcription Factor Motifs Analysis Pipeline

    HTML 47 11

  4. CRISPR-SURF Public

    Python 16 3

  5. PrimeDesign Public

    Software tool for the flexible design of pegRNAs and ngRNAs for prime editing!

    Python 23 6

  6. MotifRaptor Public

    Explore the effect of genetic variants on transcription factor binding sites

    Python 8 2

Repositories

Showing 10 of 57 repositories
  • DNA-Diffusion Public

    🧬 Generative modeling of regulatory DNA sequences with diffusion probabilistic models 💨

    Python 387 52 3 10 Updated Apr 24, 2025
  • pyrovelocity Public

    𝒫robabilistic modeling of RNA velocity ⬱

    Python 47 AGPL-3.0 5 10 17 Updated Apr 23, 2025
  • Python 5 MIT 2 5 1 Updated Apr 21, 2025
  • CRISPResso2 Public

    Analysis of deep sequencing data for rapid and intuitive interpretation of genome editing experiments

    Python 298 100 39 (1 issue needs help) 3 Updated Apr 4, 2025
  • Nextflow 1 MIT 0 0 0 Updated Apr 1, 2025
  • CRISPRme Public
    Python 21 8 1 1 Updated Mar 31, 2025
  • crisprapido Public

    use WFA2 to scan for CRISPR guide targets

    Rust 1 2 0 0 Updated Feb 26, 2025
  • crispr-bean Public

    Base Editing screens' Activity-Normalized variant effect size estimation

    Python 9 AGPL-3.0 2 1 2 Updated Feb 7, 2025
  • ACCESS-ATAC-seq Public

    Scripts for ACCESS-ATAC-seq data

    Python 1 MIT 0 0 0 Updated Jan 17, 2025
  • CRISPR-Correct Public

    Perform CRISPR guide mapping and analysis that considers protospace self-editing and surrogate sensor sequences. Self-editing aware mapping takes a hamming-distance approach unbiased by expectations in editing patterns.

    Python 2 AGPL-3.0 0 3 0 Updated Jan 15, 2025